Systemic Lupus Erythematosus (SLE)

getty_rf_photo_of_collage_of_womenSystemic lupus erythematosus (SLE), or lupus, is a systemic autoimmune condition that can affect any part of the body. Autoimmune conditions are illnesses that occur when the body’s cells and tissues are attacked by its own immune system resulting in inflammation and tissue damage. Patients with lupus produce abnormal antibodies in their blood targeting tissues (autoantibodies) as opposed to foreign infectious agents. Patients present with a myriad of complaints and symptoms; it can affect the skin, heart, lungs, kidneys, joints, and/or nervous system. When localized to the skin, without internal disease, it is called discoid lupus. Only when internal organs are involved is the condition referred to as systemic lupus erythematosus.

Who gets lupus?

Lupus is predominantly a disease of women. It may present at any age, although its peak incidence is during the childbearing years, between 15 and 45, at which time the female-to- male ratio climbs, reaching a peak ratio of approximately 12 :1. It occurs worldwide, although it is likely under-recognized and under- diagnosed in developing countries.

In the U.S., lupus is most prevalent among those of non-Caucasian descent, with those of African heritage most affected.

What are lupus symptoms?

dermnet_rf_photo_of_butterfly_rashPatients often report fatigue, low- grade-fever, loss of appetite, muscle/ joint aches, sores in the mouth and nose, facial rash over the bridge of their nose (“butterfly rash”), unusual sensitivity to sunlight, inflammation of the lining that surrounds the lungs and the heart, and poor circulation to the fingers and toes with cold exposure (Raynaud’s phenomenon). Complications may occur depending on the organ affected and the severity of the disease. Given its heterogeneous presentation, no single test can confirm and establish its diagnosis. A physician who specializes in lupus (rheumatologist) will evaluate the patient and make this clinical diagnosis.

What is the treatment for lupus?

Lupus is a chronic condition, and there is no cure yet available. However, in many cases patients can achieve remission of symptoms with prompt, appropriate treatment. Currently, there are both oral and intravenous therapies for lupus, all of which serve to control the body’s overactive immune response. Rheumatologists and patients work together to determine appropriate therapy based on the individual’s symptoms.

Additional information about lupus can be found Here.

Infusion treatment medications include: